Fisetin is a senotherapeutic that extends health and lifespan

Yousefzadeh M.J., Zhu Y., McGowan S.J. et al. · EBioMedicine, 2018

Species: Mice
Design: Preclinical / animal model
Sample: Aged mice, intermittent late-life dosing

What it found

Of ten flavonoids screened, fisetin was the most potent senolytic. Intermittent late-life dosing cleared senescent cells across tissues and extended both median and maximum lifespan.

Why it matters

Senescent cells stop dividing but refuse to die, and they poison the tissue around them. Clearing them is one of the few interventions that works when started late. Human trials remain small and early.

How much weight this carries

Early evidence

Promising mechanism with mostly preclinical or small-sample human data. We flag the uncertainty.

Read the paper→

Compounds in this study

Fisetin
A flavonoid studied for aging cells.

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