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Ingredient science and the thinking behind Our Beloved Friends — with sources. Every compound carries an honest evidence-stage badge, because the strength of the research is part of the claim.
Both are borrowed from human medicine and floated for pet ageing. Only one has a randomized trial in dogs and robust lifespan data in mammals — and it isn't the cheap, familiar one.
July 23, 2026 · 9 min read
If rapamycin isn't right for your animal, several supplements and one serious drug programme are sold as alternatives. Here's an honest ranking of what the evidence supports — and where it runs out.
July 23, 2026 · 10 min read
At the low, intermittent doses used in pet trials, serious adverse effects were uncommon and mostly mild. But rapamycin is an immunosuppressant, the long-term pet data doesn't exist yet, and some animals should never take it.
July 23, 2026 · 10 min read
It is a prescription drug, so there is no route that skips a veterinarian. Here is how the process actually works, what to ask, and how to tell a careful provider from a careless one.
July 21, 2026 · 9 min read
This is one of the most-searched questions in pet longevity, and the honest answer is uncomfortable: the dose is not a number you should take from a website — including this one.
July 21, 2026 · 9 min read
Heart function is where the canine rapamycin data is least thin. It is also one small study over ten weeks. Here's what happens to an old dog's heart, what to watch for, and how much that finding really carries.
July 21, 2026 · 9 min read
Osteoarthritis is one of the most common — and most under-treated — conditions in older dogs, largely because dogs hide pain so well. Here is what has real evidence behind it, and an honest look at the rapamycin claim.
July 20, 2026 · 10 min read
Pacing at 3am, staring at walls, forgetting the door they've used for years. Canine Cognitive Dysfunction is common in old dogs, frequently mistaken for ordinary ageing — and several of the things that mimic it are treatable.
July 20, 2026 · 10 min read
Cancer is a leading cause of death in older dogs, which makes it the area where hopeful claims spread fastest. Here is what actually lowers risk or catches it early — and an honest look at whether rapamycin belongs in that list.
July 20, 2026 · 10 min read
Chronic gingivostomatitis leaves a cat with a mouth too sore to eat. It is genuinely awful, genuinely treatable, and a magnet for immune-modulation claims that have never been tested in cats.
July 20, 2026 · 9 min read
Most indoor cats live 13–17 years, and many reach 18–20 or beyond. Here's what the numbers really are, why indoor cats outlive outdoor ones so dramatically, and which of the levers you control actually matter.
July 19, 2026 · 10 min read
A cat that's eating well but losing weight, restless, yowling at night, or drinking more — one of the most common explanations in an older cat is an overactive thyroid. It's very treatable, and it's frequently mistaken for “just getting old.”
July 19, 2026 · 9 min read
It's the disease most likely to take an old cat, and by the time the classic signs appear, much of the kidney is already gone. Here's how to catch it earlier — and why a blood test called SDMA matters so much.
July 19, 2026 · 10 min read
It is the sentence used to end every conversation about rapamycin — and it is true, at one dose, and close to backwards at another. Here is the distinction that decides everything.
July 16, 2026 · 10 min read
Kidney disease is the thing most likely to take an old cat, so it is where hope runs hardest. Here is the honest state of the evidence on mTOR inhibitors and the kidney — including the human trials that disappointed.
July 16, 2026 · 11 min read
Across species, bigger animals live longer. Within the dog, it flips: a Great Dane is old at six while a terrier is barely middle-aged. The reason runs straight through the pathway the whole longevity field is built on.
July 16, 2026 · 9 min read
The most dangerous four words in pet health are “just a smaller dose.” Cats have a specific gap in how they process drugs, and it is why a compound that is fine for a dog can kill a cat.
July 16, 2026 · 10 min read
We write about rapamycin because the science is real and moving. But if you want more good years with your dog or cat right now, the best-evidenced interventions are unglamorous, mostly free, and sitting in plain sight.
July 16, 2026 · 9 min read
The largest study of ageing in pet dogs ever run, and the trial inside it that could show a drug extends canine lifespan. What each one is actually testing — and why the honest answer today is “we don't know yet.”
July 16, 2026 · 10 min read
We went compound by compound through the ingredients sold as pet longevity supplements and graded each on honest evidence — including the ones with a beautiful mechanism and no outcome data. A field guide for the sceptical buyer.
July 16, 2026 · 12 min read
If your senior cat has started crying at night, disoriented, it is frightening and exhausting. Here is what feline cognitive dysfunction is, what else it might be, and where the ageing-brain science honestly stands.
July 16, 2026 · 10 min read
Hypertrophic cardiomyopathy is the most common heart disease in cats, it usually arrives without symptoms, and it is the one place where feline geroscience has actually been tested. What the evidence supports — and what it does not.
July 15, 2026 · 11 min read
Not at seven, and definitely not by multiplying anything by seven. Dogs age on a curve set by their adult body size; cats do not. Here are the real thresholds — and why the answer decides whether the aging research applies to your animal at all.
July 15, 2026 · 9 min read
It extended lifespan in mice from three independent labs. It has a randomized trial in pet dogs. It is also a prescription immunosuppressant that people keep describing carelessly. Here is what the evidence actually says.
June 20, 2026 · 14 min read
An honest, compound-by-compound map of the pet-longevity literature — with a graded evidence badge and primary-source citations for every molecule, including the ones that disappoint.
June 1, 2026 · 12 min read
A gut metabolite of pomegranate became one of the few longevity ingredients with replicated randomized human data. Here's the mechanism, the trials, and the honesty line.
June 3, 2026 · 9 min read
PSP, PSK, TLR2, and natural-killer cells — why a shelf fungus has a longer clinical track record than most things in the supplement aisle, and where the evidence stops.
June 5, 2026 · 8 min read
Aging and immune biology are largely conserved across mammals. Here's how we translate human and preclinical evidence into species-safe doses for pets — and where the translation gets careful.
June 7, 2026 · 7 min read
Two compounds we include with clear evidence-stage flags, because pretending they're settled would break our own rules. A look at autophagy, senolytics, and mixed human data.
June 9, 2026 · 7 min read