Aging cohorts
Emerging evidenceThe dog aging project: translational geroscience in companion animals
Kaeberlein M., Creevy K.E., Promislow D.E.L. · Mammalian Genome, 2016
- Species
- Dogs
- Design
- Review
- Sample
- Not applicable
What it found
Lays out the case for the companion dog as a translational model of aging, and for testing geroprotective interventions — rapamycin foremost among them — in animals that actually live alongside us.
Why it matters
The founding argument of the field, and a good first read. It explains why anyone is giving a cancer drug to healthy dogs in the first place.
How much weight this carries
Human trials exist but are mixed or early-stage; the mechanism is well characterized.
This link runs a PubMed search on the paper’s exact title rather than a hard-coded DOI. It always resolves to the real record, and it cannot rot.
More on aging cohorts
- LOY-002 — FDA reasonable expectation of effectiveness for extending senior dog lifespan
FDA Center for Veterinary Medicine, 2025
- An open science study of ageing in companion dogs
Nature, 2022
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