Rapamycin & mTOR
Strong human evidencemTOR inhibition improves immune function in the elderly
Mannick J.B., Del Giudice G., Lattanzi M. et al. · Science Translational Medicine, 2014
- Species
- Humans
- Design
- Randomized controlled trial
- Sample
- Adults aged 65 and older
What it found
Six weeks of a low-dose mTOR inhibitor before influenza vaccination improved the antibody response in older adults and reduced the accumulation of exhausted immune cells.
Why it matters
It demonstrated in humans that partial mTOR inhibition can rejuvenate an aging immune system rather than merely suppress it — the dose-dependence that separates a longevity protocol from a transplant protocol.
How much weight this carries
Multiple randomized human trials with consistent, replicated results. In pets the effect is inferred from conserved biology and species-appropriate dosing.
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More on rapamycin & mtor
- Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Nature, 2009
- Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice
eLife, 2016
- A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs
GeroScience, 2017
- TRIAD — Test of Rapamycin In Aging Dogs
Dog Aging Project, 2024
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