Longevity
Animal-model evidenceCalcium alpha-ketoglutarate (Ca-AKG)
A Krebs-cycle building block for cellular energy.
How it works
An intermediate of the citric-acid cycle involved in energy metabolism and epigenetic regulation; healthspan signals reported in animal models.
The evidence
Signals so far come from animal models. We carry these forward cautiously and say so.
What the evidence supports
Supports cellular energy metabolism.
The studies behind it
The primary literature for this compound, with what each paper actually found.
Read the research
- Rapamycin alternatives for aging dogs and cats: what's actually claimed, and what has evidence
If rapamycin isn't right for your animal, several supplements and one serious drug programme are sold as alternatives. Here's an honest ranking of what the evidence supports — and where it runs out.
- Do dog and cat longevity supplements work? A graded audit of the shelf
We went compound by compound through the ingredients sold as pet longevity supplements and graded each on honest evidence — including the ones with a beautiful mechanism and no outcome data. A field guide for the sceptical buyer.
- The longevity compounds, and how strong the evidence really is
An honest, compound-by-compound map of the pet-longevity literature — with a graded evidence badge and primary-source citations for every molecule, including the ones that disappoint.
- Why one science base serves both dogs and cats
Aging and immune biology are largely conserved across mammals. Here's how we translate human and preclinical evidence into species-safe doses for pets — and where the translation gets careful.
The content on this site is for informational purposes only and is not veterinary advice. These statements have not been evaluated by a food or drug regulatory authority and are not intended to diagnose, treat, cure, or prevent any disease. Always consult a licensed veterinarian about your pet's health.