Mitochondrial health
Strong human evidenceThe mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans
Andreux P.A., Blanco-Bose W., Ryu D. et al. · Nature Metabolism, 2019
- Species
- Humans
- Design
- Randomized controlled trial
- Sample
- Sedentary older adults, 250–1000 mg
What it found
Oral urolithin A was safe across single and four-week repeated doses, was bioavailable in plasma, and shifted skeletal-muscle mitochondrial gene expression toward a healthier signature.
Why it matters
The first demonstration that mitophagy — the recycling of worn-out mitochondria — can be pharmacologically nudged in a living human by something you swallow.
How much weight this carries
Multiple randomized human trials with consistent, replicated results. In pets the effect is inferred from conserved biology and species-appropriate dosing.
Compounds in this study
- Urolithin A
Helps cells clear out worn-out mitochondria.
More on mitochondrial health
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