Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health

Singh A., D'Amico D., Andreux P.A. et al. · Cell Reports Medicine, 2022

Species: Humans
Design: Randomized controlled trial
Sample: Middle-aged adults, four months

What it found

Roughly a 12% improvement in muscle strength versus placebo, with better aerobic endurance and lower C-reactive protein. The trial's single primary endpoint — peak power — did not reach significance, and we report that too.

Why it matters

Replicated randomized human data is rare on the longevity shelf. Urolithin A has it. The honest asterisk on the primary endpoint is exactly the kind of detail most supplement marketing quietly drops.

How much weight this carries

Strong human evidence

Multiple randomized human trials with consistent, replicated results. In pets the effect is inferred from conserved biology and species-appropriate dosing.

Read the paper→

Compounds in this study

Urolithin A
Helps cells clear out worn-out mitochondria.

More on mitochondrial health

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans
Nature Metabolism, 2019
Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice
Cell Metabolism, 2020

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