Spermidine

Read the research

• Rapamycin alternatives for aging dogs and cats: what's actually claimed, and what has evidence

  If rapamycin isn't right for your animal, several supplements and one serious drug programme are sold as alternatives. Here's an honest ranking of what the evidence supports — and where it runs out.

• Old dog, confused at night: canine cognitive dysfunction explained

  Pacing at 3am, staring at walls, forgetting the door they've used for years. Canine Cognitive Dysfunction is common in old dogs, frequently mistaken for ordinary ageing — and several of the things that mimic it are treatable.

• Do dog and cat longevity supplements work? A graded audit of the shelf

  We went compound by compound through the ingredients sold as pet longevity supplements and graded each on honest evidence — including the ones with a beautiful mechanism and no outcome data. A field guide for the sceptical buyer.

• The old cat yowling at 3am: feline cognitive dysfunction and the ageing brain

  If your senior cat has started crying at night, disoriented, it is frightening and exhausting. Here is what feline cognitive dysfunction is, what else it might be, and where the ageing-brain science honestly stands.

• The longevity compounds, and how strong the evidence really is

  An honest, compound-by-compound map of the pet-longevity literature — with a graded evidence badge and primary-source citations for every molecule, including the ones that disappoint.

• Spermidine and fisetin: promising, and still early — on purpose

  Two compounds we include with clear evidence-stage flags, because pretending they're settled would break our own rules. A look at autophagy, senolytics, and mixed human data.